Viral evolution in chronic hepatitis B: a branched way to HBeAg seroconversion and disease progression?
نویسندگان
چکیده
منابع مشابه
Diagnosis and management of chronic viral hepatitis: antigens, antibodies and viral genomes.
Virological tools, including serological and molecular tools, are needed to diagnose chronic hepatitis B and C infections. They may also be useful to establish their prognosis, but they have found their principal application in guiding treatment decisions and assessing the virological responses to therapy. The goal of chronic hepatitis B therapy is to prevent progression of liver disease. This ...
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HBeAg seroconversion is an important stage in the evolution of a chronic hepatitis B virus (HBV) infection that usually leads to control of viral replication and a reduced risk for liver cirrhosis and cancer. Since current therapies for the HBV-associated liver inflammation that is known as chronic hepatitis B (CHB). Rarely induce permanent HBeAg seroconversion, there is a need to understand th...
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Human APOBEC3 (A3) cytosine deaminases are antiviral restriction factors capable of editing the genome the hepatitis B virus (HBV). Despite the importance of the human A3 protein family for the innate immune response little is known about the clinical relevance for hepatitis B. The aim of this study was to utilize ultra-deep pyrosequencing (UDPS) data to analyse the phenomenon of G-to-A hypermu...
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Hepatitis B virus (HBV) is a partially double-stranded DNA virus, which is a major causative agent of chronic, acute hepatitis, liver cirrhosis and hepatocellular carcinoma in Asian, African and Southern European countries. An estimated 350 to 400 million carriers are found around the world (Wang et al., 2005) and 1 to 2 million people have died from this virus (Mahoney, 1999). In India the pre...
متن کاملAssociation between KIR Genes and Efficacy of Treatment of HBeAg-Positive Chronic Hepatitis B Patients with Entecavir
Background: Entecavir (ETV) is commonly used to treat chronic hepatitis B (CHB) in China. However, certain percentages of e-Antigen (HBeAg) positive CHB patients do not respond to ETV therapy. Objective: To investigate whether the killer immunoglobulin-like receptor (KIR) genes were associated with seroconversion in HBeAg positive CHB responder patients treated with ETV. Methods: Polymerase cha...
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عنوان ژورنال:
- Gut
دوره 62 9 شماره
صفحات -
تاریخ انتشار 2013